Opticlear Eye & Ear Drops contain Chloramphenicol, Dexamethasone and Polymyxin B. It is a combination of two antibiotics (Chloramphenicol , Polymyxin B) and a steroid ( Dexamethasone ). The antibiotics work by killing the bacteria or stopping their growth. Together, they treat your infection effectively. The steroid blocks the production of certain chemical messengers (prostaglandins) that make the affected area red, swollen and itchy.